Curcumin and Arthritis

Natural products as a gold mine for arthritis treatment

Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB.
Current Opinions in Pharmacology
2007, 7(3):344-51

Curcumin inhibits the expression of gene products linked to rheumatic diseases

The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis

Jackson JK, Higo T, Hunter WL, Burt HM. Inflammation Research 2006, 55(4):168-75

Both agents inhibited neutrophil activation, synoviocyte proliferation and angiogenesis.

Curcumin strongly inhibited collagenase and stromelysin expression whereas quercetin had no effect in this assay.

Suppression of NF-kB activation by curcumin leads to inhibition of expression of COX-2 and MMP-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis

Shakibaei M, John T, Schulze-Tanzil G, Lehmann I. Mobasheri A.
Biochemical Pharmacology
2007, 73(9):1434-45

Curcumin induces apoptosis and inhibits PGE(2) production in synovial fibroblasts of patients with rheumatoid arthritis

Park C, Moon DO, Choi IW, Choi BT, Nam TJ, Rhu CH, Kwon TK, Lee WH, Kim GY, Choi YH. International Journal of Molecular Medicine 2007, 20(3):365-72

Curcumin decreased the expression levels of the cyclooxygenase (COX)-2 mRNA and protein without causing significant changes in the COX-1 levels.

Oncostatin M-induced MMP and TIMP-3 genes expression in chondrocytes requires JAK/STAT signaling pathway

Li WQ, Dehnade F, Zafarullah M. Journal of Immunology 2001, 166(5):3491-8.

Curcumin suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and JNK activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.

Curcumin also inhibited OSM-induced MMP-1, MMP-3, MMP-13, and TIMP-3 gene expression.

Inhibition of IL-1-stimulated MAP kinases, AP-1 and NF-kB down-regulates MMP gene expression in articular chondrocytes

Liacini A. Matrix Biology 2002, 21(3):251-62

Inhibition of IL-1 signal transduction by these agents could be useful for reducing cartilage resorption by MMPs in arthritis.

Interleukin-18 induces the production of VEGF in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways

Cho ML, Jung YO, Moon YM, Min SY, Yoon CH, Lee SH, Park SH, Cho CS, Jue DM, Kim HY. Immunology Letters 2006;103:159-66

Curcumin dose-dependently abrogated the effect of IL-18 on VEGF production.

Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin

Joe B. Molecular & Cellular Biochemistry 1997;169:125-34

Gp A72, acidic glycoprotein (pI of 5.1); has antitryptic activity and appears in the serum before the onset of paw inflammation in arthritic rats and persists during the chronic phase

Oral administration of the capsaicin and curcumin lowered the levels of Gp A72 by 88 and 73% respectively with concomitant lowering of paw inflammation in arthritic rats.

Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells

Lev-Ari S. Rheumatology 2006;45:171-7

This effect may enable the use of celecoxib at lower and safer concentrations, and may pave the way for a novel combination treatment in osteoarthritis and other rheumatological disorders.

Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis

Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Sólyom AM, Timmermann BN. Journal of Natural Products 2006;69:351-5

The in vivo efficacy of curcuminoid in the prevention or treatment of arthritis using streptococcalcell wall (SCW)-induced arthritis in rats, was examined.

Arthritic index, a clinical measure of joint swelling, was used as the primary endpoint for assessing the effect on joint inflammation.

Curcuminoids was efficacious in preventing joint inflammation when treatment was started before, but not after, the onset of joint inflammation.

Modulation of inflammatory mediators by ibuprofen and curcumin treatment during chronic inflammation in rat

Banerjee M, Tripathi LM, Srivastava VM, Puri A, Shukla R. Immunopharmacology & Immunotoxicology 2003;25:213-24

The in vivo efficacy of curcuminoid in the prevention or treatment of arthritis using streptococcalcell wall (SCW)-induced arthritis in rats, was examined.

The effect of curcumin on the overall immune response of the body during adjuvant induced chronic inflammation in rat was examined.

Preliminary study on anti-rheumatic activity of curcumin

Deodhar SD, Sethi R, Srimal RC. Indian Journal of Medical Research 1980;71:632-4

Antirheumatic activity of curcumin